Development and Application of Biomarkers for Thiamin Deficiency

Grant: # 0876

Grant Amount: $180,000.00

Board Decision Year: 2007

Michigan State University - Department of Fisheries and Wildlife (East Lansing)

Department of Fisheries and Wildlife

Li, Weiming (liweim@msu.edu) (517) 432-6705

GLFT - Ecosystem Health and Sustainable Fish Populations-C - Ecological and biological fisheries research to inform management

Project Details

Early mortality syndrome (EMS) causes significant fry mortality in salmonine and may limit their abundance in Lakes Michigan, Huron, and Ontario. Biologists have found strong evidence that links EMS to thiamin deficiency in Great Lakes salmonines. Michigan State University's Department of Fisheries and Wildlife induced thiamin deficiency and then analyzed expression of 10K genes in salmonines embryos with a cDNA microarray (gene chip). Biomarkers developed from these experiments are used as a diagnostic of thiamin deficiency in feral fish.

Documents

Final Report
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